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Protective effect of Rhus chinensis Mill. extract against liver cirrhosis in rats

Article scientifique 2022 Anglais

Résumé

Purpose: To study the effect of Rhus chinensis Mill. extract (RCME) on diethylnitrosamine (DEN)-induced liver cirrhosis in rats. Methods: RCME was obtained by extracting the dried Rhus chinensis Mill. in water. Liver cirrhosis rat model was prepared by injecting with DEN once a week for 8 weeks. After 8th-week of RCME treatment, biochemical index and oxidative stress were determined in DEN-induced liver cirrhosis in rats. Results: Compared with model group, plasma concentrations of alanine transaminase (ALT, 125.3 ± 4.1 U/L) and aspartate aminotransferase (AST, 152.4 ± 3.5 U/L) decreased significantly (p < 0.01) in the 8th week. Rhus chinensis Mill. extract (RCME) significantly decreased malondialdehyde (MDA, 0.18 ± 0.02 umol/L) and superoxide dismutase (SOD, 0.76 ± 0.05 U/mg protein) in DEN-induced liver cirrhosis in rats (p < 0.01) when compared with model group. Conclusion: RCME protects against diethylnitrosamine-induced liver cirrhosis in rats. However, further investigations are required to ascertain the plant extract’s suitability for the clinical management of liver cirrhosis.

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Pan, Z., Cheng, Q., Chen, H., Lin, L., Liao, W., Guo, D., Zhuang, J. (2022). Protective effect of Rhus chinensis Mill. extract against liver cirrhosis in rats. https://doi.org/10.4314/tjpr.v20i2.21

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Zirong Pan Qiang Cheng Heyan Chen Longhai Lin Weijia Liao Donglai Guo Jianmin Zhuang

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