Evaluation of the therapeutic potential of vomit seed (Strychnos nux-vomica) homeopathic treatment in acute acetaminophen-induced toxicity
Résumé
Purpose: To investigate the effect of vomit seed homeopathic drugs (14CH and 30CH) on paracetamolinduced toxicity in rats. Methods: Thirty-two male Wistar rats were divided into 4 groups of 8 animals each (n = 8) and treated for 12 days. During the treatment period, group (G) one (G1) which constitutes the control group received filtered water, whereas groups two (G2), three (G3), and four (G4) were gavaged with a toxic dose of paracetamol 1/4 of LD50. Next, Strychnos nux-vomica (0.5 mg/kg) homeopathic dilutions of 14CH and 30CH were administered to G3 and G4, respectively. Hematological, biochemical, and antioxidant markers were assessed. Results: Homeopathic drug groups, namely G3 and G4, showed significant recovery in some hematological (red blood cells count and hemoglobin concentration; p < 0.01) and biochemical parameters (urea, creatinine, glutamic transaminase, and alkaline phosphatase; p < 0.001). The level of malondialdehyde significantly decreased while glutathione level significantly increased in treated rats. Conclusion: The antioxidant and anti-hemolytic properties of vomit seeds protect against paracetamolinduced acute toxicity in rats by reducing oxidative stress, hepatotoxicity, and nephrotoxicity in rats.
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