Editorial: Novel antimicrobials and antibiotics resistance modulating agents from natural products: Turning promises into Triumphs

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Editorial on the Research Topic Novel antimicrobials and antibiotics resistance modulating agents from natural products: Turning promises into Triumphs With the global rise of antibiotics-resistant microbes and the ability of many microbial strains to form complex biofilms, researchers have been encouraged to search for natural products with reported antibiofilm capabilities as safer alternatives to hazardous chemicals and good resources for new antimicrobial leads (Edmond et al., 2021).Natural antimicrobials can be life-saving if well-implemented, literature suggested their efficacy in tackling food-borne pathogens, fungal infections, urinary tract diseases, and many others (El-Nashar et al., 2021a; El-Nashar et al., 2021b;Edmond et al., 2021).They can also target infected organs by loading on different carriers via implementation of nanotechnologies providing higher bioavailability, efficient delivery and reducing drug doses (Zhang et al., 2021).We cannot also ignore the increasing applications of biotechnology in this regard, including the modulation of natural products on molecular basis and the production of antimicrobials from bacteria and fungi rendering this approach a promising arena in modern therapy (Ahmed Sheikh, 2010).Natural products can be obtained from different sources as plants, animals, marine organisms and their associated endophytic bacteria and fungi (Ayoub et al., 2010;Mostafa et al., 2021).They contain a variety of secondary metabolites with interesting bioactivities (Mostafa, 2018;Moussa et al., 2020) and are thus under consideration for the discovery and development of novel drugs against various disorders including infectious diseases (Ayaz et al., 2017; Ovais et al., 2019b;Mostafa et al., 2022).An impressive number of research articles and review manuscripts were submitted to this Research Topic for consideration and a total of seven manuscripts were accepted for publication.Mohsin et al. ) analyzed the anti-onychomycosis potential of Allium sativum, Zingiber officinale, Nigella sativa, Curcuma longa, Withania somnifera, Azadirachta indica, and Lawsonia inermis.Crude samples were phytochemically analyzed via RP-HPLC revealing rutin, gallic acid, catechin, syringic acid, emodin, luteolin, myricetin, quercetin, and antifungal potential against dermatophytes, non-dermatophytes, Candida albicans, and

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