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Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Article scientifique 2021 Anglais

Résumé

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.

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Alatise, O., Knapp, G., Sharma, A., Chatila, W., Arowolo, O., Olasehinde, O., Famurewa, O., Omisore, A., Komolafe, A., Olaofe, O., Katung, A., Ibikunle, D., Egberongbe, A., Olatoke, S., Agodirin, S., Adesiyun, O., Adeyeye, A., Kolawole, O., Olakanmi, A., Arora, K., Constable, J., Shah, R., Basunia, A., Sylvester, B., Wu, C., Weiser, M., Seier, K., Gönen, M., Stadler, Z., Kemel, Y., Vakiani, E., Berger, M., Chan, T., Solit, D., Shia, J., Sánchez-Vega, F., Schultz, N., Brennan, M., Smith, J., Kingham, T. (2021). Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. https://doi.org/10.1038/s41467-021-27106-w

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Auteur(s)

Olusegun Isaac Alatise Gregory Knapp Avinash Sharma Walid K. Chatila Olukayode Arowolo Olalekan Olasehinde O. Famurewa Adeleye Dorcas Omisore Akinwumi Oluwole Komolafe Olaejirinde Olaniyi Olaofe Aba Katung David Eyitayo Ibikunle Adedeji A. Egberongbe Samuel Olatoke Sulaiman Olayide Agodirin O A M Adesiyun Ademola Adeyeye Oladapo Kolawole Akinwumi O. Olakanmi Kanika Arora Jeremy Constable Ronak Shah Azfar Basunia Brooke E. Sylvester Chao Wu Martin R. Weiser Kenneth Seier Mithat Gönen Zsofia K. Stadler Yelena Kemel Efsevia Vakiani Michael F. Berger Timothy A. Chan David B. Solit Jinru Shia Francisco Sánchez-Vega Nikolaus Schultz Murray F. Brennan J. Joshua Smith T. Peter Kingham

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