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The status of occult HBV infection in a high endemic region: risk of community HBV transmission and reactivation

Article scientifique 2025 Anglais

Résumé

OBJECTIVES: Occult hepatitis B virus (OBI) infection, characterized by the presence of HBV DNA in the absence of detectable HBsAg in the blood, is considered a potential hidden pathway for HBV transmission and reactivation, which can lead to liver cancer. This study aimed to assess the prevalence of OBI in a region of Uganda with high HBV endemicity, in order to help explain variations in HBV distribution within the country. RESULTS: Among the 387 participants who tested negative for HBsAg, the majority were women (240 individuals, 62.0%), married (242 individuals, 62.5%), and aged 30 years or older (207 individuals, 53.5%). The OBI was detected in 21 participants (5.43%). Most of those with OBI were 30 years old or younger (13 individuals, 61.9%), male (12 individuals, 57.1%), had normal liver enzyme levels, and showed an average viral load of 194.4 IU/mL with a standard deviation (SD) of ± 122.05.

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Kafeero, H., Ocama, P., Ndagire, D., Walusansa, A., Namusoke, M., Kudamba, A., Muwanda, F., Sendagire, H. (2025). The status of occult HBV infection in a high endemic region: risk of community HBV transmission and reactivation. https://doi.org/10.1186/s13104-025-07337-6

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Auteur(s)

Hussein Mukasa Kafeero Ponsiano Ocama Dorothy Ndagire Abdul Walusansa Mariam Namusoke Ali Kudamba Fahad Muwanda Hakim Sendagire

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