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Pharmacogenomic Overlap Between Antidepressant Treatment Response in Major Depression & Antidepressant Associated Treatment Emergent Mania in Bipolar Disorder

Article scientifique 2023 Anglais

Résumé

Abstract There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for the depressive phase of bipolar disorder with oftentimes an inadequate treatment response and or clinical concern for mood destabilization. This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in bipolar disorder (BD). We conducted a genome-wide association study (GWAS) and polygenic score analysis of TEM and tested its association with a subset of BD-I patients treated with SSRIs or SNRIs. Our results did not identify any genome-wide significant variants although, we found that a higher polygenic score (PGS) for antidepressant response in MDD was associated with higher odds of TEM in BD. Future studies with larger transdiagnostic cohorts treated with antidepressants are encouraged to identify a neurobiological mechanism associated with a spectrum of depression improvement (response- emergent mania).

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Núñez, N., Coombes, B., Beaupre, L., Özerdem, A., Gardea‐Resendez, M., Romo‐Nava, F., Bond, D., Veldić, M., Singh, B., Moore, K., Betcher, H., Kung, S., Prieto, M., Fuentes, M., Ercis, M., Miola, A., Sánchez-Ruiz, J., Jenkins, G., Batzler, A., Leung, J., Cuéllar‐Barboza, A., Tye, S., McElroy, S., Biernacka, J., Frye, M. (2023). Pharmacogenomic Overlap Between Antidepressant Treatment Response in Major Depression & Antidepressant Associated Treatment Emergent Mania in Bipolar Disorder. https://doi.org/10.21203/rs.3.rs-3045012/v1

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Auteur(s)

Nicolás A. Núñez Brandon J. Coombes Lindsay Melhuish Beaupre Ayşegül Özerdem Manuel Gardea‐Resendez Francisco Romo‐Nava David J. Bond Marin Veldić Balwinder Singh Katherine M. Moore Hannah K. Betcher Simon Kung Miguel L. Prieto Manuel Enrique Fuentes Mete Ercis Alessandro Miola Jorge A. Sánchez-Ruiz Gregory D. Jenkins Anthony J. Batzler Jonathan G. Leung Alfredo B. Cuéllar‐Barboza Susannah J. Tye Susan L. McElroy Joanna M. Biernacka Mark A. Frye

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