Association of the rapid decline in kidney function with the rapid deterioration of health-related quality of life in chronic kidney disease: finding from the KNOW-CKD study

Résumé

Abstract This study aimed to evaluate changes in health-related quality of life (HRQOL) in patients with chronic kidney disease (CKD) according to the decline in kidney function. HRQOL was assessed using the Short from-36 questionnaire composed of a physical component summary (PCS) and mental component summary (MCS). The rapid decline of kidney function was defined as a decline in estimated glomerular filtration rate (eGFR) of > 3 mL/min/1.73 m2/year. The rapid deterioration of HRQOL was defined as higher than the median of the changes in HRQOL values. Among 970 patients, 360 (37.1%) were in the rapid kidney function decline group. In 720 patients who were 1:1 propensity score-matched, the baseline eGFR was not significantly different between the non-rapid and rapid kidney function decline groups. Compared with the baseline PCS, the 5-year PCS decreased in the non-rapid and rapid kidney function decline groups before and after PSM. Five-year MCS significantly decreased only in the rapid kidney function decline group. In propensity score-matched patients, rapid decline in kidney function was significantly associated with the rapid deterioration of PCS (odds ratio [OR]: 1.48; 95% confidence interval [CI]:1.07–2.05; P = 0.018) and MCS (OR:1.89; 95% CI:1.36–2.62; P < 0.001). The rapid decline in kidney function was associated with the rapid deterioration of HRQOL in CKD patients.

Citer ce document

Accès au document

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0