Structural and bioactivity evaluation of molybdenum-doped phosphate glasses: drug delivery application

Résumé

Abstract Boro-phosphate glasses of stoichiometric chemical formula of (50-x)P2O5-20B2O3- 20CaO-10Na2O (x = 5–15 mol. % MoO3), have been prepared using melt-quenching technique. Structural and bioactivity properties of these glasses were considered. The bioactivity was evaluated upon 14 days of soaking in simulated body fluid (SBF) using: XRD, FT-IR and SEM. Through these techniques the creation of the calcium phosphate biolayer as one of the transitional yields of biomineralization is affirmed. Moreover, glass samples were examined as a drug delivery for ciprofloxacin (CIP) antibiotic. It was noticed that the higher the MoO3 content the faster was the drug release rate. Textural analysis elucidated that by increasing the content of MoO3, the surface area was increased. Mathematical models help to design a controlled drug release system. CIP in vitro release mechanism was determined by fitting different dissolution data into two different release models Zero Order and Higuchi model.

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