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Frequency of Anti-HCV, HBsAg, HIV1-p24 Antigen, Acid Fast Bacilli and Plasmodium spp., in Herbal Home and Hospital Patients with Elevated TNFα (≥ 5.0 pg/ml) in Saki, West Nigeria

Article scientifique 2019 Anglais

Résumé

Infectious agents and chemical substances can trigger the production and the release of cytokines. To determine the pattern of infectious agents in herbal homes patients with elevated TNF ( 5.0 pg/ml) in Saki -West-Nigeria. The subjects include patients with elevated TNF ( 5.0 pg/ml) in 15 herbal homes(n=23 ; aged 5-69 years; males -13 ; females -10) and patients with elevated TNF in 3 major hospitals (n = 32; aged 6 -67years; males -12 ; females -20). Plasma TNF, anti-HCV, HBsAg and HIV1-p24 antigen were determined by ELISA, Plasmodium spp., by Giemsa thick film staining and Acid Fast Bacilli by Ziehl-Nelson staining. The frequency of infectious agents obtained in the patients include 4.3 %(1) anti-HCV; 17.4% (4) HBsAg; 4.3 %(1) HIV1-p24 antigen; 17.4% (4) Plasmodium spp.; 8.7 %(2) Acid Fast Bacilli and 4.3 %(1) HBsAg + Plasmodium spp., in patients of herbal homes and 6.3 %(2) anti-HCV; 9.4% (3) HBsAg; 3.1 %(1) HIV1-p24 antigen; 15.6% (6)Plasmodium spp., 0%(0) Acid Fast Bacilli and 3.1 %(1) HBsAg + Plasmodium spp., in patients of the three major hospitals. The frequency of those with 5.0 -6,0 pg/ml TNF (65.2% ( The pattern of the infectious agents was more in herbal home patients with 5.0 -6,0 pg/ ml TNF than those with 6.1 -6, 8 pg/ml TNF while in hospital patients it was more in those with 6.1 -6,8 pg/ml TNF than those with 5.0 -6,0 pg/ml TNF. The overall frequency of the infectious agents was more in herbal homes patients (58.5%(13)) than 37.5%(12) obtained in hospital patients. The frequency of viral immunochemical biomarkers, Acid Fast Bacilli and Plasmodium spp., was more in herbal home patients than the patients recruited from the hospital which varies with the TNF range.

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Olaniyan, M., Azeez, M. (2019). Frequency of Anti-HCV, HBsAg, HIV1-p24 Antigen, Acid Fast Bacilli and Plasmodium spp., in Herbal Home and Hospital Patients with Elevated TNFα (≥ 5.0 pg/ml) in Saki, West Nigeria. https://doi.org/10.22207/jpam.13.2.19

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Mathew Folaranmi Olaniyan Mufutau Mosunmade Azeez

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