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Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study

Article scientifique 2022 Anglais

Résumé

Abstract Background: The Democratic Republic of the Congo (DRC) is one of the countries with the highest rotavirus mortality rate in the world. The aim of this study was to describe the clinical features of rotavirus infection after the introduction of rotavirus vaccination of children in the city of Kisangani, DRC. Methods: We conducted a cross-sectional study of acute diarrhoea in children under 5 years of age admitted to 4 hospitals in Kisangani, DRC. Rotavirus was detected in children's stools by an immuno-chromatographic antigenic rapid diagnostic test. Results: A total of 165 children under 5 years of age were included in the study. We obtained 59 with rotavirus infection, or 36% CI95 [27, 45]. The majority of children with rotavirus infection were unvaccinated (36 cases) and had watery diarrhoea (47 cases), of high frequency 9.6±3.4 and accompanied by severe dehydration (30 cases). Conclusion: Rotavirus infection in hospitalized children under 5 years of age is characterized by a severe clinical manifestation. Epidemiological surveillance is needed to identify risk factors associated with the infection.

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Gbebangi-Manzemu, D., Kampunzu, V., Vanzwa, H., Mumbere, M., Bukaka, G., Likele, B., Kasaï, E., Mukinay, B., Tonen‐Wolyec, S., Dauly, N., Opara, J. (2022). Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study. https://doi.org/10.21203/rs.3.rs-2387699/v1

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Didier Gbebangi-Manzemu Véronique Muyobela Kampunzu Hortense Malikidogo Vanzwa Mupenzi Mumbere Gaspard Mande Bukaka Bibi Batoko Likele Emmanuel Tebandite Kasaï Benoit Mbiya Mukinay Serge Tonen‐Wolyec Nestor Ngbonda Dauly Jean Pierre Alworong’a Opara

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