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Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out

Article scientifique 2020 Anglais

Résumé

Tuberculosis (TB) misdiagnosis remains a public health concern, especially among people living with HIV (PLHIV), given the high mortality associated with missed TB diagnoses. The main objective of this study was to describe the all-cause mortality, TB incidence rates and their associated risk factors in a cohort of PLHIV with presumptive TB in whom TB was initially ruled out. We retrospectively followed a cohort of PLHIV with presumptive TB over a 2 year-period in a rural district in Southern Mozambique. During the study period 382 PLHIV were followed-up. Mortality rate was 6.8/100 person-years (PYs) (95% CI 5.2-9.2) and TB incidence rate was 5.4/100 PYs (95% CI 3.9-7.5). Thirty-six percent of deaths and 43% of TB incident cases occurred in the first 12 months of the follow up. Mortality and TB incidence rates in the 2-year period after TB was initially ruled out was very high. The TB diagnostic work-up and linkage to HIV care should be strengthened to decrease TB burden and all-cause mortality among PLHIV with presumptive TB.

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García, J., Mambuque, E., Nguenha, D., Vilanculo, F., Sacoor, C., Sequera, G., Fernández-Quevedo, M., Pierre, M., Chiconela, H., Faife, L., Respeito, D., Saavedra, B., Nhampossa, T., López‐Varela, E., García‐Basteiro, A. (2020). Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out. https://doi.org/10.1038/s41598-020-71784-3

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Auteur(s)

Juan Ignacio García Edson Mambuque Dinis Nguenha Faustino Vilanculo Charfudin Sacoor Guillermo Sequera Manuel Fernández-Quevedo Maxime Leroux-La Pierre Hélio Chiconela Luis A. Faife Durval Respeito Belén Saavedra Tacilta Nhampossa Elisa López‐Varela Alberto L. García‐Basteiro

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