Evaluation of urinary Binax Now for diagnosis of pneumococcal pneumonia in children

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Abstract Purpose Rapid diagnosis of pneumococcal pneumonia is challenging and current tools are limited by various factors. Comprehensive approach, which may increase accuracy of diagnosis and hence precise management is mandatory. The aim of the present study was to ascertain whether the urinary antigin test (Binax NOW) can add information and improve diagnostic yields when combined to conventional methods (ie, blood cultures, sputum cultures, molecular techniques). Methods This cross sectional study included 60 infants and children with pneumonia recruited from the pediatrics emergency room, inpatient departments and pediatric ICU. Thirty matched healthy control were enrolled. Cases were evaluated for the severity of community acquired pneumonia by CAP Severity of illness in children and PRESS score. The urinary antigin test( Binax NOW) ,induced sputum culture, blood culture ,PCR,CBC, CRP are tested simultaneously. Results Binax NOW was found of significance when compared to severity indices, the CRP levels and PCR values of the studied children(p-value < 0.001). The BinaxNow has sensitivity of 75% and specificity of 100%. Conclusion The urinary Binax NOW antigen test is a useful adjunct for rapid diagnosis of pneumococcus pneumonia with the potential to impact patient care and improve antibiotic stewardship.

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