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A promising azeotrope-like mosquito repellent blend

Article scientifique 2017 Anglais

Résumé

Topical repellents play a key role in reducing the outdoor transmission of mosquito-borne diseases by reducing human-vector contact. Excellent repellents are available, but there is always room for improvement. This article reports on a particularly effective binary repellent blend of ethyl butylacetylaminopropionate and nonanoic acid. A composition containing 25 mol% of the acid exhibits negative pseudo-azeotrope behaviour at 50 °C, meaning that the liquid vapour pressure is lower than that of the parent compounds and evaporation occurs without a change in the liquid composition. In tests performed using the South African Medical Research Council's cup-on-arm procedure, this mixture provided better protection for a longer time than the "gold standard of mosquito repellents", namely N,N-diethyl-m-toluamide, commonly known as DEET.

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Izadi, H., Focke, W., Asaadi, E., Maharaj, R., Pretorius, J., Loots, M. (2017). A promising azeotrope-like mosquito repellent blend. https://doi.org/10.1038/s41598-017-10548-y

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