Effectiveness and safety of ziv aflibercept in myopic choroidal neovascularisation patients

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Abstract Background: Myopic choroidal neovascularization (CNV) is the most common sight threatening complication in high myopia. The present study evaluates the efficacy and safety of intravitreal injection of ziv-aflibercept in patients with myopic CNV. Methods: This is a prospective interventional study that was conducted on 20 eyes of 20 patients with active myopic CNV. Twelve patients were 40 years old or more. The study was performed in Ophthalmology department, Tanta University Eye Hospital ,Tanta University, Egypt. Complete ophthalmic evaluation was performed including best corrected visual acuity (BCVA), fundus examination and anterior segment examination. OCT was done for all patients at baseline and monthly after injection during the 6 months follow up period of the study. Statistical calculations were performed using the computer program SPSS (S tatistical Package for the Social Science) . Results: The younger age group received lower number of injections than the older age group, the best corrected visual acuity ( BCVA) and the central macular thickness (CMT) improved significantly in both groups with more improvement in the younger age group as regarding the BCVA. No significant correlation was found between the final BCVA and both the spherical equivalent and the central macular thickness after 6 months.No significant changes in IOP after intravitreal injection were detected in both groups .No complications were reported apart from mild sub conjunctival hemorrhage that occurred in three eyes after injection. Conclusion: Ziv-aflibercept is a highly effective and safe drug in cases of active myopic CNV that can produce similar results to other anti VEGF agents with less cost. The study was retrospectively registered with clinical trial .gov ID (NCT04290195) in 26-2-2020.

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