Patients with tuberculosis and diabetes show altered clinical and biochemical parameters during anti-TB treatment

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Abstract Type-2 diabetes mellitus (DM) increases tuberculosis (TB) risk and can worsen treatment outcomes. Both diseases and their treatments induce significant metabolic and biochemical perturbations that influence disease progression and management. This study longitudinally evaluated clinical, metabolic, and serum biochemical changes in patients with pulmonary TB with and without DM before and during anti-TB therapy. Ninety-five adult patients newly diagnosed with pulmonary TB in Ghana were stratified into TB-Only ( n = 49; HbA1c < 6.5%) and TB-DM ( n = 46; HbA1c ≥ 6.5%) groups, including treated (TB-DMt) and untreated (TB-DMnt) diabetes subgroups. Serum samples collected at baseline (t 0 ), day 28 (t 28 ), and day 56 (t 56 ) were analyzed for electrolytes, renal function, liver enzymes, and lipid profiles using validated clinical chemistry analyzer. TB-DM cohorts exhibited significantly lower chloride levels at all time points relative to the TB-Only cohort (e.g., 98 vs. 100 mmol/L at t 0 , p < 0.001). Hyponatremia (serum sodium < 136 mmol/L) was prevalent during the intensive anti-TB treatment phase, affecting 53.1% of TB-Only patients, 61.1% of TB-DMt patients, and 70.0% of TB-DMnt patients. Liver function tests revealed elevated bilirubin, gamma-glutamyl transferase (g-GT), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) levels, particularly in TB-DMnt patients, with normalization over time. Lipid profiles showed a pro-atherogenic pattern with elevated triglycerides and total cholesterol ( p < 0.05). High-density and low-density lipoproteins were increased at select time points. Positive correlations were noted among albumin, cholesterol fractions, and electrolytes. Primary microbiological treatment outcomes, including sputum conversion and completion rates, were similar regardless of diabetic status. The distinctive metabolic and biochemical derangements in TB-DM, especially untreated diabetes, highlight the importance of integrated clinical management. Elevated hepatic enzymes in TB-DMnt may delay metformin initiation, suggesting a need to optimize timing post hepatic recovery, while the prevalence of hyponatremia underscores the need for routine electrolyte monitoring in TB patients with diabetes. The dysregulated lipid profile highlights cardiovascular risk that warrants routine monitoring. Despite metabolic challenges, effective TB treatment outcomes are achievable with comprehensive care.

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