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Neuronal firing and DNA dynamics in a neural network

Article scientifique 2018 Anglais

Résumé

We study the mutual effects of neuronal electrical activity and DNA dynamics in a network of electrically coupled neurons with nearest neighbors communication. For that we develop by means of the coupling function method, a mathematical DNA-neuron model that can be considered as an extension of the simplified Hodgkin-Huxley models. Numerically, we explore the biological properties of the model with emphasis on local phase transitions and synchronous neural activity. Our results suggest that firing and coherent behavior of neural network are controlled by DNA dynamics. Conversely, neuronal activity induces DNA electrochemical denaturation. As a result, we expect that the prominent DNA-neuron model would be worth in controlling gene expression and neurodegenerative diseases in the sensory thalamus.

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Etémé, A., Tabi, C., Ateba, J., Ekobena, H., Mohamadou, A., Kofané, T. (2018). Neuronal firing and DNA dynamics in a neural network. https://doi.org/10.1088/2399-6528/aaf3f7

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Auteur(s)

Armand Sylvin Etémé Conrad Bertrand Tabi Jean Félix Beyala Ateba H.P.F. Ekobena Alidou Mohamadou Timoléon Crépin Kofané

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