Comparison of a Virtual Reality-Based Visual Field Device (Oculera) with Humphrey Visual Field Analyzer in Glaucoma Patients and Healthy Individuals

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Abstract Background/objectives: To examine the correlation between Humphrey visual field analyzer and an automated virtual reality perimetry test (Oculera visual field analyzer) in glaucoma patients and healthy individuals. Methods: This prospective, single-center study was conducted on 93 eyes of 93 patients, 55 of whom were glaucoma patients (glaucoma group) and 38 healthy subjects (normal group). HFA II (24-2, Swedish Interactive Threshold Algorithm) and Oculera (24-2, Oculera Interactive) tests were applied to all participants. Mean deviation (MD) values ​​of both devices were analyzed. The correlation between the two devices was assessed with statistical analyses on MD. The Bland-Altman plot was used to display the level of agreement between the two devices. Results: The MDs were -6.36 dB (-31.8 to 2.27) for HFA II MD and -5.80 dB (-29.1 to 2.2) for Oculera MD. The difference between MDs of Oculera and HFA II was -0.56 dB. Dependent t-test showed a statistically significant difference between Oculera and HFA II (mean -0.55; 95% CI -0.885 to -0.229; p < 0.001). Also, the correlation of MDs was quite strong (r = 0.995 and p < 0.001). In the subgroup analysis, comparable results were observed with both devices in all three groups among mild, moderate, and advanced glaucoma patients. Conclusions: A good correlation was found between standard automatic perimetry and Oculera. Oculera MD results were comparable to HFA II MD results. Oculera may be a useful alternative in clinical practice for functional testing in glaucoma patients. It also offers convenience as it is portable and can be applied at home.

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