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Quantitative Immunohistochemical Expression of GP88 in Invasive Ductal Carcinoma (IDC) of Human Breast Cancer

Article scientifique 2020 Anglais

Résumé

Abstract Background: Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. This work was aimed to investigate the digital expression of GP88, and HER2/neu as a predictive biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues, as well as, its correlation with different pathological parameters.Methods: The immunohistochemical avidin-biotin complex protocol of the paraffin section was used to detect the expression of GP88 and HER2/neu in IDC of 60 patients, 30 benign, and ten normal breast tissues. Results: the study showed a high expression of GP88 in IDC comparing to normal and benign breast tissues. A higher significant statistical correlation between the expression of GP88 and large tumor size, tumor grade, and lymph node metastasis (LNM). While a negative statistical correlation was noticed between the expression of GP88 and ER, PR, and HER2/neu status.Conclusion: It could be concluded that GP88 glycoprotein may be a valuable predictive and therapeutic marker in human IDC patients.

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Yehia, M., El-Fiky, S., AL-Qadasi, S., Sedfy, A. (2020). Quantitative Immunohistochemical Expression of GP88 in Invasive Ductal Carcinoma (IDC) of Human Breast Cancer. https://doi.org/10.21203/rs.3.rs-66892/v1

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Mona Abdel-Hamed Yehia Shawky M. El-Fiky Sabah Ali AL-Qadasi Amel Sobhey El- Sedfy

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