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Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Article scientifique 2016 Anglais

Résumé

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

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Jelenkovic, A., Sund, R., Hur, Y., Yokoyama, Y., Hjelmborg, J., Möller, S., Honda, C., Magnusson, P., Pedersen, N., Ooki, S., Aaltonen, S., Stazi, M., Fagnani, C., D’Ippolito, C., Freitas, D., Maia, J., Ji, F., Ning, F., Pang, Z., Rebato, E., Busjahn, A., Kandler, C., Saudino, K., Jang, K., Cozen, W., Hwang, A., Mack, T., Gao, W., Yu, C., Li, L., Corley, R., Huibregtse, B., Derom, C., Vlietinck, R., Loos, R., Heikkilä, K., Wardle, J., Llewellyn, C., Fisher, A., McAdams, T., Eley, T., Gregory, A., He, M., Ding, X., Bjerregaard-Andersen, M., Beck‐Nielsen, H., Sodemann, M., Tárnoki, Á., Tárnoki, D., Knafo‐Noam, A., Mankuta, D., Abramson, L., Burt, S., Klump, K., Silberg, J., Eaves, L., Maes, H., Krueger, R., McGue, M., Pahlen, S., Gatz, M., Butler, D., Bartels, M., Craig, J., Saffery, R., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N., Medland, S., Montgomery, G., Swan, G., Krasnow, R., Tynelius, P., Lichtenstein, P., Haworth, C., Plomin, R., Bayasgalan, G., Danshiitsoodol, N., Harden, K., Tucker–Drob, E., Spector, T., Mangino, M., Lachance, G., Baker, L., Tuvblad, C., Duncan, G., Buchwald, D., Willemsen, G., Skytthe, A., Kyvik, K., Christensen, K., Öncel, S., Alıev, F., Rasmussen, F., Goldberg, J., Sørensen, T. (2016). Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. https://doi.org/10.1038/srep28496

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Auteur(s)

Aline Jelenkovic Reijo Sund Yoon-Mi Hur Yoshie Yokoyama Jacob Hjelmborg Sören Möller Chika Honda Patrik K. E. Magnusson Nancy L. Pedersen Syuichi Ooki Sari Aaltonen Maria A. Stazi Corrado Fagnani Cristina D’Ippolito Duarte Freitas José Maia Fuling Ji Feng Ning Zengchang Pang Esther Rebato Andreas Busjahn Christian Kandler Kimberly J. Saudino Kerry L. Jang Wendy Cozen Amie E. Hwang Thomas M. Mack Wenjing Gao Canqing Yu Liming Li Robin P. Corley Brooke M. Huibregtse Cathérine Derom Robert Vlietinck Ruth J. F. Loos Kauko Heikkilä Jane Wardle Clare Llewellyn Abigail Fisher Tom A. McAdams Thalia C. Eley Alice M. Gregory Mingguang He Xiaohu Ding Morten Bjerregaard-Andersen Henning Beck‐Nielsen Morten Sodemann Ádám Domonkos Tárnoki Dávid László Tárnoki Ariel Knafo‐Noam David Mankuta Lior Abramson S. Alexandra Burt Kelly L. Klump Judy L. Silberg Lindon J. Eaves Hermine H. Maes Robert F. Krueger Matt McGue Shandell Pahlen Margaret Gatz David A. Butler Meike Bartels Jeffrey M. Craig Richard Saffery Lise Dubois Michel Boivin Mara Brendgen Ginette Dionne Frank Vitaro Nicholas G. Martin Sarah E. Medland Grant W. Montgomery Gary E. Swan Ruth E. Krasnow Per Tynelius Paul Lichtenstein Claire M. A. Haworth Robert Plomin Gombojav Bayasgalan Narandalai Danshiitsoodol K. Paige Harden Elliot M. Tucker–Drob Timothy D. Spector Massimo Mangino Geneviève Lachance Laura A. Baker Catherine Tuvblad Glen E. Duncan Dedra Buchwald Gonneke Willemsen Axel Skytthe Kirsten Ohm Kyvik Kaare Christensen Sevgi Yurt Öncel Fazil Alıev Finn Rasmussen Jack Goldberg Thorkild I. A. Sørensen

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