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Hepcidin and iron metabolism in preterm infants

Article scientifique 2023 Anglais

Résumé

Background Iron deficiency (ID) and ID anemia are widespread in low-income countries, particularly among preterm infants. Hepcidin is a key regulator of iron metabolism, which offers the possibility of new solutions to diagnose ID in premature infants. Objective To explore the relationship between iron metabolism and hepcidin in premature infants. Materials and methods The study involved 81 preterm infants between 28+1 and 36+6 who underwent iron status indicators and hepcidin testing at 6 months of corrected gestational age. The preterm infants were divided into two groups based on iron status indicators: ID and no ID. Results Serum hepcidin was lower for premature infants with ID compared to those without ID (log10hepcidin, 1.18 ± 0.44 vs 1.49 ± 0.37, p = 0.002). A single-variate linear regression model was used to explore the correlation between hepcidin and other indicators of iron metabolism. A strongly positive relationship was observed between hepcidin levels and ferritin levels (p < 0.001) in the correlation analysis. Conclusions Hepcidin can be used as an efficient indicator of iron storage and a promising indicator for the early diagnosis of ID in premature infants.

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Ruan, S., Yang, S., Li, J., Xiong, F., Qie, D., You, L., Tang, Z., Yang, F. (2023). Hepcidin and iron metabolism in preterm infants. https://doi.org/10.3934/molsci.2023008

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Auteur(s)

Sufeng Ruan Sufei Yang Jinrong Li Fei Xiong Di Qie Lu You Zhanghui Tang Fan Yang

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