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Brief communication: targeted serum proteomics in postpartum South African women living with and without HIV, correlations with anthropometry and adiposity

Article scientifique 2025 Anglais

Résumé

Postpartum adiposity is associated with long-term risk of cardiovascular disease (CVD), which may be influenced by HIV infection. We investigated cross-sectional correlations between postpartum adiposity measures, and circulating proteins linked to CVD in women living with and without HIV. Irrespective of HIV status, adiposity was positively correlated with fatty acid binding protein 4, leptin and galectin 9; and negatively correlated with insulin-like growth factor binding protein 2 and V-set immunoglobulin domain containing 2. The link between adiposity and CVD-linked circulating proteins underscores the role of protein markers in understanding the cardiometabolic health of postpartum women living with and without HIV. Clinical trial number: Not applicable.

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Madlala, H., Chen, J., Jao, J., Myer, L., Mendham, A., Pheiffer, C., Bell, L., Dugas, L., Goedecke, J., Sun, Y., Bengtson, A. (2025). Brief communication: targeted serum proteomics in postpartum South African women living with and without HIV, correlations with anthropometry and adiposity. https://doi.org/10.1186/s12981-025-00782-0

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Auteur(s)

Hlengiwe P. Madlala Junyu Chen Jennifer K. Jao Landon Myer Amy E. Mendham Carmen Pheiffer Liam Bell Lara R. Dugas Julia H. Goedecke Yan V. Sun Angela M. Bengtson

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