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Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019

Article scientifique 2023 Anglais

Résumé

Viral infections of the central nervous system (CNS) are common worldwide and result in considerable morbidity and mortality associated with neurologic illness. Until now, there have been no epidemiologic data regarding viruses causing aseptic meningitis, encephalitis, and CNS infections in Egypt. We investigated 1735 archived cerebrospinal fluid samples collected from Egyptian patients between 2016 and 2019 and performed molecular characterization for infection for12 different viruses: herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesviruses 6 and 7 (HHV-6 and HHV-7), human enteroviruses (HEVs), human parechovirus (HPeV), parvovirus B19 (B19V), adenovirus (AdV), and mumps virus (MuV). All included samples were negative for bacterial infection. Our results indicated a relatively high prevalence of viral infection, with HEVs being the most prevalent viruses, followed by HSV-1, EBV, and then HSV-2. The highest prevalence was among male patients, peaking during the summer. Data obtained from this study will contribute to improving the clinical management of viral infections of the CNS in Egypt.

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Roshdy, W., Kandeil, A., Fahim, M., Naguib, N., Mohsen, G., Shawky, S., El-Fattah, M., Naguib, A., Salamony, A., Shamikh, Y., Moawad, M., Guindy, N., Khalifa, M., Abbas, E., Galal, R., Hassany, M., Ibrahem, M., El‐Shesheny, R., Asem, N., Kandeel, A. (2023). Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019. https://doi.org/10.1186/s12985-023-02079-y

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Auteur(s)

Wael H. Roshdy Ahmed Kandeil Manal Fahim Nourhan Y. Naguib Gehad Mohsen Shaymaa Shawky Marwa M. Abd El-Fattah Amel Naguib Azza Salamony Yara I. Shamikh Mahmoud Moawad Nancy El Guindy Mohamed K. Khalifa Eman M. Abbas Ramy Galal Mohamed Hassany Mohamed Ibrahem Rabeh El‐Shesheny Noha Asem Amr Kandeel

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