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Molecular detection of airborne Emergomyces africanus, a thermally dimorphic fungal pathogen, in Cape Town, South Africa

Article scientifique 2018 Anglais

Résumé

Emergomyces africanus is a thermally dimorphic fungus that causes a systemic mycosis in immunocompromised persons in South Africa. Infection is presumed to follow inhalation of airborne propagules. We developed a quantitative PCR protocol able to detect as few as 5 Es. africanus propagules per day. Samples were collected in Cape Town, South Africa over 50 weeks by a Burkard spore trap with an alternate orifice. We detected Es. africanus in air samples from 34 days (10%) distributed over 11 weeks. These results suggest environmental exposure to airborne Es. africanus propagules occurs more commonly in endemic areas than previously appreciated.

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Schwartz, I., McLoud, J., Berman, D., Botha, A., Lerm, B., Colebunders, R., Levetin, E., Kenyon, C. (2018). Molecular detection of airborne Emergomyces africanus, a thermally dimorphic fungal pathogen, in Cape Town, South Africa. https://doi.org/10.1371/journal.pntd.0006174

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Auteur(s)

Ilan S. Schwartz Josh D. McLoud Dilys Berman Alfred Botha Barbra Lerm Robert Colebunders Estelle Levetin Chris Kenyon

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