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The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

Article scientifique 2017 Anglais

Résumé

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.

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Kiaco, K., Rodrigues, A., Rosário, V., Gil, J., Lopes, D. (2017). The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome. https://doi.org/10.1186/s12936-017-2006-6

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Auteur(s)

Kinanga Kiaco António Sebastião Rodrigues Virgı́lio do Rosário José Pedro Gil Dinora Lopes

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