Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies
Résumé
Abstract Prucalopride (PCP) is a medication used for the management of constipation via regulating bowel motions. PCP is widely used all over the world. So, novel, rapid, and highly sensitive carbon dots N-CQDs were obtained fromEruca Sativajuice via microwave approach in 4 min. The luminescence power of N-CQDs was declined by the increasing prucalopride concentration at emission 518 nm with linearity ranged from 3.00 to 200.00 ng mL−1. The luminescent antecedent was utilized for the test of PCP in human plasma with the rate of recovery extending from 95.06 to 98.40%. The new technique is an eco-friendly analytical method that can be easily applied in clinical laboratories. This assay is also simple, sensitive, and applied to therapeutic laboratories and subsequent pharmacokinetic studies in several clinical laboratories. Furthermore, the N-CQDs nano-sensor was able to distinguish the target drug from interferents commonly found in human plasma, indicating its high specificity and selectivity for PCP detection.
Citer ce document
Accès au document
Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter
Voir l'article sur le site de la revueAuteur(s)
Statistiques
Consultations : 1
Téléchargements : 0