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Thiamethoxam evoked neural oxido-inflammatory stress in male rats through modulation of Nrf2/NF-kB/iNOS signaling and inflammatory cytokines: neuroprotective effect of silymarin.

Article scientifique 2022 Anglais

Résumé

Abstract Thiamethoxam, a neonicotinoid insecticide, is a widely used insecticide with neurotoxic potential. This study explored the neuroprotective effects of silymarin on thiamethoxam-triggered cortical injury in male rats. Animals were divided into four groups and treated daily either with SM (150 mg/kg), TMX (78.15 mg/kg), or both at the aforementioned doses for 28 days. Our results revealed marked declines in cortical SOD and CAT activities with elevations in MDA, IL-1b and TNF-α levels in thiamethoxam-treated rats. Further, thiamethoxam induced down-regulation in gene expressions of Sod, Cat, Gpx, and Nrf-2 genes, with up-regulation in the expression of IL-1b, IL-6, iNOS, TNF-α and NF-kB genes. Interestingly, pre-treatment with SM provided a notable neuroprotective action against TMX-mediated cortical damage that indicates its promising antioxidant and anti-inflammatory activities. This effect may be mediated by Nrf2/NF-kB/iNOS signalling and suppression of excess free radicals and production of inflammatory cytokines.

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Habotta, O., Ateya, A., Saleh, R., El‐Ashry, E. (2022). Thiamethoxam evoked neural oxido-inflammatory stress in male rats through modulation of Nrf2/NF-kB/iNOS signaling and inflammatory cytokines: neuroprotective effect of silymarin.. https://doi.org/10.21203/rs.3.rs-1562776/v1

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Ola A. Habotta Ahmed Ateya Rasha M. Saleh Eman S. El‐Ashry

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