Accès ouvert

Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

Article scientifique 2016 Anglais

Résumé

Why mammals have poor regenerative ability has remained a long-standing question in biology. In regenerating vertebrates, injury can induce a process known as epimorphic regeneration to replace damaged structures. Using a 4-mm ear punch assay across multiple mammalian species, here we show that several Acomys spp. (spiny mice) and Oryctolagus cuniculus completely regenerate tissue, whereas other rodents including MRL/MpJ 'healer' mice heal similar injuries by scarring. We demonstrate ear-hole closure is independent of ear size, and closure rate can be modelled with a cubic function. Cellular and genetic analyses reveal that injury induces blastema formation in Acomys cahirinus. Despite cell cycle re-entry in Mus musculus and A. cahirinus, efficient cell cycle progression and proliferation only occurs in spiny mice. Together, our data unite blastema-mediated regeneration in spiny mice with regeneration in other vertebrates such as salamanders, newts and zebrafish, where all healthy adults regenerate in response to injury.

Citer ce document

Gawriluk, T., Simkin, J., Thompson, K., Biswas, S., Clare-Salzler, Z., Kimani, J., Kiama, S., Smith, J., Ezenwa, V., Seifert, A. (2016). Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals. https://doi.org/10.1038/ncomms11164

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Thomas R. Gawriluk Jennifer Simkin Katherine Thompson Shishir Biswas Zak Clare-Salzler John M. Kimani Stephen G. Kiama Jeramiah J. Smith Vanessa O. Ezenwa Ashley W. Seifert

Statistiques

Consultations : 3

Téléchargements : 0