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HPV genotypes and epidemiology in women cervical cancer in Senegal.

Article scientifique 2020 Anglais

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Abstract Background In sub-Saharan Africa, cervical cancer is increasing steadily, with more than 75,000 new cases and nearly 50,000 deaths a year (Mboumba et al., 2017). In Senegal, pathologies such as cervical cancer are at the top of the causes of death and Human papillomavirus (HPV) is the aetilogical agent (Steenbergen et al., 2005). Methods The aim of the study is to analyze the distribution of HPV among Senegalese women with cervical cancer. Main objectives of this study are to identify the HPV types associated or “co-associated” with cervical oncogenesis in Senegal. The correlations with risk factors of cervix carcinogenesis, with risk factors, were analyze too. Cervical biopsies were performed on women hospitalized at Aristide Hospital Le Dantec-Julio Curie Institute. Three methods has been used to detect HPV genotypes - SANGERsequencing genotyping (Applied BioSystems), PCR real-time approach technique (HPV 16 & 18 RealTime PCR kit) (www.bioneer.co.kr) and the genotyping approach from Chippron (HPV kit 3.5 LCDArray) (info@chipron.com). Results It this study, patients had multiple infections (co-infections) at all, and the majority of coinfections was High-risk types (HR-HPV types). The most common type of HPV in our study were 16 (systematically detected in more than half of our patients), 18 (44%), 45 (33%), 33 (31%), 59 (28%), 35 (12%), 31 (11%), 58 (8%), 39 and 73 (4%), 44, 54 and 68 (3%) and the rest less than 1%. . Among co-infections detected in different regions of Senegal among women with cervical cancer, we found that HPV types 16 and 18 had the highest prevalence. In the Dakar region, which had the highest number of cases, a prevalence of 17.89% of HR-HPV co-infections was noted. Conclusion Polygamy represents a cofactor in the occurrence of cervical cancer in Senegalese women. No association between HPV-High Risk co-infections and cancer stages.

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NIANE, k., Diagne, C., Diop, G., Dia, N., Talla, C., Loucoubar, C., Ndiaye, M., Niang, M., Aissatou, D., Ka, S., Dièye, A., Sall, A., Dem, A. (2020). HPV genotypes and epidemiology in women cervical cancer in Senegal.. https://doi.org/10.21203/rs.2.15323/v2

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kHADIDIATOU NIANE Cheikh Tidiane Diagne Gora Diop Ndongo Dia Cheikh Talla Cheikh Loucoubar Moussa Ndiaye Mbayame Ndiaye Niang Diallo Aissatou Sidy Ka Alioune Dièye Amadou Alpha Sall Ahmadou Dem

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