Accès ouvert

Anti-inflammatory assessment of zinc oxide nanoparticles mediated Aframomum citratum (C. Pereira) K. Schum (Zingiberaceae) in Wistar rats

Article scientifique 2024 Anglais

Résumé

Abstract Introduction Zinc oxide nanoparticles (ZnONPs) have been synthesized using a wide range of techniques, including green chemistry, because of their versatility, cost effectiveness, and environmentally friendly nature, offering thereby interesting and inexpensive therapeutic options. This study aimed to develop zinc oxide nanoparticles as an anti-inflammatory agent using Aframomum citratum seed extract. Methodology ZnONPs were prepared by the reaction between zinc nitrate and an alkalineaqueous extract of A. citratum seeds. The isolated nanoparticles were then characterized using UV-Vis, FTIR, SEM/EDX, PXRD and TEM techniques. The toxicological profile was assessed at a limited dose of 2000 mg/kg in rats, and methods for heat denaturation of egg albumin, stabilization of red blood cell membranes and inhibition of carrageenan-induced plantar oedema were studied to assess anti-inflammatory properties. Results The formation of ZnONPs was observed by a color change and the appearance of the plasmon resonance peak at 360 nm in the UV-Vis spectrum while FTIR confirmed the presence of secondary metabolites; SEM confirmed the presence of multiform aggregates, and TEM visualize point like particles. EDS confirmed the presence of Zn atoms within the synthetized material. The toxicological profile studied showed no harmful signs; zinc oxide nanoparticles synthesized from A. citratum seed extract showed high inhibition percentages of 86 (1mg/mL); 77 (0.6mg/mL) and 79(1mg/mL) when subjected to inhibition of heat-induced egg albumin denaturation, red cell membrane stabilization and oedema induction by carrageenan respectively, not significatively different compared with diclofenac sodium as positive controls. Conclusion Zinc oxide nanoparticles synthesized and characterized from A. citratum seed extract act as a potent anti-inflammatory agent and are devoid of acute oral toxicity.

Citer ce document

Meva, F., Essama, D., Nguemfo, E., Bamal, H., Ntoumba, A., Kedi, P., Beglau, T., Djimefo, A., Djuidje, A., Tchatchouang, G., Nanga, C., Nyuyfoni, G., Njimou, A., Evouna, D., Fongang, A., Janiak, C. (2024). Anti-inflammatory assessment of zinc oxide nanoparticles mediated Aframomum citratum (C. Pereira) K. Schum (Zingiberaceae) in Wistar rats. https://doi.org/10.1101/2024.12.15.628600

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

François Eya’ane Meva Denise Murielle Nga Essama Edwige Laure Nguemfo Hans-Denis Bamal Agnes Antoinette Ntoumba Phillipe Belle Ebanda Kedi Thi Hai Yen Beglau Alex Kevin Tako Djimefo Annie Guilaine Djuidje Geordamie Chimi Tchatchouang Chick Christian Nanga Gildas Fonye Nyuyfoni Armel Florian Tchangou Njimou Danielle Ines Madeleine Evouna Armel Ulrich Mintang Fongang Christoph Janiak

Statistiques

Consultations : 3

Téléchargements : 0