Accès ouvert

Diagnostic performance of fecal Helicobacter pylori antigen test in Uganda

Article scientifique 2022 Anglais

Résumé

We evaluated the diagnostic performance of a qualitative stool antigen test (SAT) in individuals with dyspepsia in rural Uganda using the polymerase chain reaction-based 16S ribosomal RNA assay (16S rRNA) for nucleotide sequences for two common H. pylori-associated genes as the reference standard. We enrolled 150 adults with dyspepsia with no self-reported use of antibiotic and/or antiacid medication medications within a fortnight. We performed blinded SAT on fecal specimens and 16S rRNA tests on gastric specimens. Using nonlinear mixed models, SAT had a sensitivity of 85⋅1% (95%CI 76⋅54%, 93⋅6%), and specificity of 97⋅6% (95%CI 94⋅3, 100). Twelve individuals with dyspepsia need to be tested to correctly diagnose 10 with H. pylori infection using SAT. The SAT is a robust diagnostic test to improve the diagnosis of H. pylori infection in people with dyspepsia in resource-limited settings.

Citer ce document

Owot, J., Tuhumwire, C., Tumuhimbise, C., Tusiime, F., Emmanuel, B., Lumori, B., Okello, S. (2022). Diagnostic performance of fecal Helicobacter pylori antigen test in Uganda. https://doi.org/10.1186/s12876-022-02551-z

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Jacob Canwat Owot Caleb Tuhumwire Christine Tumuhimbise Florence Tusiime Byaruhanga Emmanuel Boniface Amanee Elias Lumori Samson Okello

Statistiques

Consultations : 1

Téléchargements : 0