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Prognosis of Colorectal Cancer in Tikur Anbessa Specialized Hospital, the Only Oncology Center in Ethiopia

Article scientifique 2019 Anglais

Résumé

Abstract BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer in males and the second in females worldwide. According to Addis Ababa cancer registry, it is the first in male and fourth in female in Ethiopia. However, there have not been studies on prognostic factors and survival of colorectal cancer. Hence, this study aimed to estimate survival time and identify prognostic factors. METHODS: In this institution based retrospective study, medical records review of 422 colorectal cancer patients and telephone interview was used as sources of data. Survival time was estimated using Kaplan-Meier estimator. Prognostic factors were identified using the multivariable Cox regression model. RESULTS: The median survival time was 39 months. The overall five years survival rate was 33%. Patients diagnosed with rectal cancer had 76% (HR: 1.761, 95% CI: 1.173-2.644) increased risk to die compared to colon cancer patients. Node positive patients were 3.146 (95% CI: 1.626-6.078) times likely to die compared to node negative and metastatic cancer were 4.221 (95% CI: 2.788-6.392) times likely to die compared to non-metastatic patients. Risk of death was 36.1% lesser (HR: 0.639 (95% CI: 0.418-0.977)) among those who received adjuvant therapy compared to patients who had only surgical resection. CONCLUSION: The overall survival rate is low and majority of patients were young adults at presentation. Patient’s survival is largely influenced by advanced stage at presentation and delays in administration of adjuvant therapy. Adjuvant therapy was among the good prognostic factors. Implementation of colorectal cancer screening program and early detection with timely and advanced treatment are crucial to increase patients’ survival time. KEY WORDS: Colorectal cancer, survival, prognostic factor, Cox regression, Tikur Anbessa Specialized Hospital, Addis Ababa.

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Etissa, E., Assefa, M., Ayele, B. (2019). Prognosis of Colorectal Cancer in Tikur Anbessa Specialized Hospital, the Only Oncology Center in Ethiopia. https://doi.org/10.21203/rs.2.13961/v1

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Eyob Kebede Etissa Mathewos Assefa Assefa Birhanu Ayele

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