Accès ouvert

Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model

Article scientifique 2022 Anglais

Résumé

BACKGROUND: The difficulty of achieving targeted drug delivery following administration of presently marketed anticancer therapeutics is still a concern. Metallic nanoparticles (NPs) appear to be promising in this regard. The present study focused on the use of gold nanoparticles (AuNPs) as a drug carrier for anticancer Doxorubicin (DOX) forming DOX-AuNPs nanocomposite. The anticancer effect of the prepared nanocomposite was evaluated using SRP essay on breast cancer cell line (MCF7) for different incubation times (24 h,48, and72hr). The prepared DOX-AuNPs nanocomposite was investigated by UV-visible spectroscopy, TEM, fluorescence spectroscopy, and FTIR spectroscopy. RESULTS: Our results showed that the prepared AuNPs and DOX-AuNPs nanocomposite have spherical and small size10 ± 2 nm and 12 ± 2 nm respectively. The potential cytotoxicity of the DOX-AuNPs nanocomposite on the MCF7 cell line was significantly increased compared to free DOX. The 20 µM DOX- AuNPs nanocomposite produced a similar decrease in cell survival as 80 µM free DOX. CONCLUSION: Future work is in progress to investigate the positive effects of the prepared nanocomposite for chemo-photothermal combination treatment.

Citer ce document

Faid, A., Shouman, S., Badr, Y., Sharaky, M. (2022). Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model. https://doi.org/10.1186/s13065-022-00889-9

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Amna H. Faid Samia A. Shouman Yehia Badr Marwa Sharaky

Statistiques

Consultations : 1

Téléchargements : 0