Prognostic Value of Immunoscore in Colorectal Carcinomas

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Abstract Background Immunoscore (IS), based on the evaluation of CD3 + and CD8 + densities in the center of the tumor (CT) and its invasive margin (IM), is currently considered as a potential prognostic factor, particularly in colorectal carcinomas (CRC). In the current study, we aimed to assess the prognostic value of IS in CRC stage I to IV, through a survival study. Methods It was a descriptive and retrospective study involving 104 cases of CRC. Data were collected over three years (2014–2016). An immunohistochemical study (anti-CD3, anti-CD8) by the Tissue Microarray (TMA) technique was carried out in the areas of "Hot Spot" in CT and IM. A percentage was assigned to each marker and within each region. Then, the density was classified as "Low" or "High", according to a cut-off fixed at the median of percentages. IS was calculated by the method described by Galon et al. The prognostic value of the IS was assessed through a survival study. Results The mean age of patients was 61.63 years. IS was low in 60.6% (n = 63). Our study had shown that low IS significantly deteriorates survival and a high IS enhances survival significantly (p < 0.001). We found a correlation between IS and T stage (p = 0.026). A multivariate showed that the predictive factors for survival were IS (p = 0.001) and age (p = 0.035). Conclusion IS is a potential prognostic factor. Its reproducibility and reliability allow its introduction into daily practice for better therapeutic management.

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