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Editor's evaluation: Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis

Article scientifique 2023 Anglais

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Background: Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand the characteristic immunopathology of tuberculosis.We performed targeted metabolomic analyses in a large cohort of patients with tuberculous meningitis (TBM), the most severe manifestation of tuberculosis, focusing on tryptophan metabolism.Methods: We studied 1069 Indonesian and Vietnamese adults with TBM (26.6% HIV-positive), 54 non-infectious controls, 50 with bacterial meningitis, and 60 with cryptococcal meningitis.Tryptophan and downstream metabolites were measured in cerebrospinal fluid (CSF) and plasma using

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Kana, B. (2023). Editor's evaluation: Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis. https://doi.org/10.7554/elife.85307.sa0

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Bavesh D Kana

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