Accès ouvert

Evaluating utility and feasibility of mismatch repair testing of colorectal cancer patients in a low-middle-income country

Article scientifique 2022 Anglais

Résumé

Molecular pathology services for colorectal cancer (CRC) in Sudan represent a significant unmet clinical need. In a retrospective cohort study involving 50 patients diagnosed with CRC at three major medical settings in Sudan, we aimed to outline the introduction of a molecular genetic service for CRC in Sudan, and to explore the CRC molecular features and their relationship to patient survival and clinicopathological characteristics. Mismatch repair (MMR) and BRAF (V600E) mutation status were determined by immunohistochemistry. A mismatch repair deficient (dMMR) subtype was demonstrated in 16% of cases, and a presumptive Lynch Syndrome (LS) diagnosis was made in up to 14% of patients. dMMR CRC in Sudan is characterized by younger age at diagnosis and a higher incidence of right-sided tumours. We report a high mortality in Sudanese CRC patients, which correlates with advanced disease stage, and MMR status. Routine MMR immunohistochemistry (with sequential BRAF mutation analysis) is a feasible CRC prognostic and predictive molecular biomarker, as well as a screening tool for LS in low-middle-income countries (LMICs).

Citer ce document

Elsayed, I., Geraghty, R., Mekki, S., Mohamedani, A., Ahern, S., Salim, O., Khalil, B., Abdelrahim, S., Suliman, S., Elhassan, M., Salah, S., Salih, M., Widatalla, A., Abdelhamed, O., Wang, X., Ryan, É., Winter, D., Bakhiet, S., Sheahan, K. (2022). Evaluating utility and feasibility of mismatch repair testing of colorectal cancer patients in a low-middle-income country. https://doi.org/10.1038/s41598-022-14644-6

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Inas Elsayed Robert Geraghty Salwa O. Mekki Ahmed Abdalla Mohamedani Susan Ahern Omer Elfaroug Salim Balgis B. M. Khalil Sawsan Abdelrahim Suliman H. Suliman Moawia Mohammed Ali Elhassan Salah O. Salah Mohamed E Salih AbuBakr H. Widatalla Osman S. Abdelhamed Xiaosheng Wang Éanna J. Ryan D. C. Winter Salih Bakhiet Kieran Sheahan

Statistiques

Consultations : 1

Téléchargements : 0