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Zinc Nanoparticles Induced Oxidative Stress, Genotoxicity and Apoptosis in Haemocytes of Bombyx mori Larvae

Article scientifique 2022 Anglais

Résumé

Abstract The expanded uses of zinc oxide nanoparticles (ZnO-NPs) have grown rapidly in the field of nanotechnology. Thus, the increased production of nanoparticles (NPs) increases the potential risks to the environment and occupationally exposed humans. Hence, safety toxicity assessment including genotoxicity of these NPs is indispensable. In the present study, we have evaluated the genotoxic effect of ZnO-NPs on 5th larval instar of Bombyx mori after feeding on mulberry leaves treated with ZnO-NPs at concentrations 50 and 100μg/ml. Moreover, evaluated its effects on total and different haemocyte count, antioxidant potential and catalase activity on the haemolymph of treated larvae. Results showed that ZnO-NPs at concentrations 50 µg/l and100 µg/ml significantly decreased the total haemocyte count (THC) and different haemocyte count (DHC) except the number of Oenocyte it significantly increased. Gene expression profile also showed up-regulation of GST, CNDP2 and CE genes suggesting increase in antioxidant activity and alteration in cell viability as well as cell signaling.

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Belal, R., Gad, A. (2022). Zinc Nanoparticles Induced Oxidative Stress, Genotoxicity and Apoptosis in Haemocytes of Bombyx mori Larvae. https://doi.org/10.21203/rs.3.rs-1662991/v1

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Rania Belal Abir A. Gad

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