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Helicobacter pylori associated aberrant methylation genes in blood leukocyte and gastric mucosa
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Background and Aim: Methylation alterations may be involved in Helicobacter pylori-associated gastric carcinogenesis. This study aims to explore the potential H.pylori-associated methylation biomarkers in blood leukocyte and gastric mucosa. Methods: Five candidate H.pylori-associated aberrant methylation genes were selected from the previous genome-wide profiling panels and validated in blood leukocyte and gastric mucosa in multi-stages (case-control validation between H.pylori positive and negative subjects and self-control validation before and after anti-H.pylori treatment).
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Zhang, Y., Chen, D., Zhang, L., Ma, J., Zhou, T., Li, Z., Liu, W., You, W., Pan, K.
(2021). Helicobacter pylori associated aberrant methylation genes in blood leukocyte and gastric mucosa.
https://doi.org/10.7150/jca.64613
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