Applications of Spectral Mathematical Processes for Estimation Stability Test of Dinitolimide in the Presence of an Acidic Degradant

Résumé

Abstract simple, rapid, sensitive, accurate and precise spectrophotometric stability-indicating methods were developed for the determination of dinitolimide in bulk powder and in pharmaceutical preparation. Method (A) First derivative (1D), Method (B) Ratio derivative (1DD), Method (C) Ratio difference (RD), Method (D) Bivariate and Method (E) Dual wavelength methods were used for the determination of intact dinitolimide in presence of its degradation product. These methods were validated and successfully applied to the determination of Zoamix ® 50mg powder with an average percent recovery { ± RSD% of 100.56 ± 1.280 for method (A), 100.07 ± 1.885 for method (B), 98.22 ± 1.414 for method (C), 99.96 ± 1.370 for method (D) and 99.05 ± 0.745 for method (E) and 98.75 ± 1.815 for method (F)}. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0