Accès ouvert

Genetic associations with carotid intima-media thickness link to atherosclerosis biology with sex-differences in sub-Saharan Africans

Article scientifique 2021 Anglais

Résumé

Abstract Atherosclerosis precedes the onset of many clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men) aged 40 to 60 years resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci, SIRPA (p=4.7E-08), and FBXL17 (p=2.5E-08), were identified in the combined dataset. Sex-stratified analysis revealed associations with two male-specific loci, SNX29 (p=6.3E-09) and MAP3K7 (p=5.3E-08), and two female-specific loci, LARP6 (p=2.4E-09) and PROK1 (p=1.0E-08). Regional associations were replicated with known risk loci for atherosclerosis and CVDs with different lead SNPs than in Europeans and significant enrichment for oestrogen response genes for female-specific signals were identified. The genes identified showed biological relevance to atherosclerosis and/or CVDs, as well as sex-differences and transferability of signals from non-African studies.

Citer ce document

Boua, P., Brandenburg, J., Choudhury, A., Sorgho, H., Nonterah, E., Agongo, G., Asiki, G., Micklesfield, L., Choma, S., Gómez‐Olivé, F., Hazelhurst, S., Tinto, H., Crowther, N., Mathew, C., Ramsay, M. (2021). Genetic associations with carotid intima-media thickness link to atherosclerosis biology with sex-differences in sub-Saharan Africans. https://doi.org/10.21203/rs.3.rs-147838/v1

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Palwendé Romuald Boua Jean‐Tristan Brandenburg Ananyo Choudhury Hermann Sorgho Engelbert A. Nonterah Godfred Agongo Gershim Asiki Lisa K. Micklesfield Solomon Choma F. Xavier Gómez‐Olivé Scott Hazelhurst Halidou Tinto Nigel J. Crowther Christopher G. Mathew Michèle Ramsay

Statistiques

Consultations : 1

Téléchargements : 0