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Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population

Article scientifique 2016 Anglais

Résumé

This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population. A total of 556 GDM patients and 500 Non-GDM were included. Eighteen single nucleotide polymorphisms (SNPs) were evaluated. Fifteen tag SNPs were selected from HapMap CHB database with a minor allele frequency of >0.2 and r(2) of >0.8. Three additional SNPs were also chosen because these SNPs are associated with type 2 diabetes in East Asians. TCF7L2 rs290487, rs6585194, and rs7094463 polymorphisms were found to be significantly associated with GDM. In multivariate analysis, rs290487 genetic variation (OR = 2.686 per each C allele, P = 0.002), pre-BMI > 24 kg/m(2) (OR = 1.592, P = 0.018), age > 25 years (OR = 1.780, P = 0.012) and LDL-C > 3.6 mmol/L (OR = 2.034, P = 0.009) were identified as independent risk factors of GDM, rs7094463 genetic variation (OR = 0.429 per each G allele, P = 0.005) was identified as independent protect factor of GDM. This finding suggests that TCF7L2 rs290487, and rs7094463 were a potential clinical value for the prediction of GDM.

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Ye, D., Yang, F., Ling, Q., Xu, W., Zhang, Z., Shu, J., Li, C., Dong, F. (2016). Polymorphisms in TCF7L2 gene are associated with gestational diabetes mellitus in Chinese Han population. https://doi.org/10.1038/srep30686

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Auteur(s)

Dan Ye Fei Yang Qi Ling Weiwei Xu Zhe Zhang Jing Shu Chengjiang Li Fengqin Dong

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