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Effects of parenteral nutrition of ω-3 polyunsaturated fatty acid, arginine and glutamine on cellular immune status of patients following liver cancer surgery

Article scientifique 2018 Anglais

Résumé

Purpose: To study the effects of parenteral nutrition (TPN), ω-3 polyunsaturated fatty acid (PUFA), Larginine (Arg), and glutamine on cellular immunity of patients who have done the liver cancer (LC) surgery.Methods: Seventy-five (75) LC patients were randomly divided into 5 groups (A - E; 15 cases each), group A, B, C, D and E, in which patients were treated with TPN, TPN + fish oil, TPN + Arg, TPN + glutamine, and TPN + ω-3 PUFA + Arg + glutamine, respectively. Before and after surgery, CD3 +, CD4 + and CD8 + were measured by antibody-sensitized erythrocyte rosette test, and IL-6, IL-10 and TNF-a were assayed with double-antibody sandwich enzyme-linked immunoassay (DAS-ELISA). IgA and IgM were measured nephelometrically.Results: The levels of CD3 +, CD4 + and CD8 + in group A showed no obvious change after surgery (p > 0.05). However, CD3 + and CD4 + increased in groups B, C and D, while CD8 + decreased in group E (p < 0.05). IL-6 in group E was lower than that in any of the other four groups (p < 0.05). IL-10 in group A was lower than that in groups B, C and D, but lower than in group E (p < 0.05). The levels of TNF-a in groups B and C were lower than those in group A, but higher than that in group E (p < 0.05) but lower than in group D. IgA in group E was higher than in the other groups (p < 0.05), while IgM level in group E was lower than in groups A, B and C (p < 0.05).Conclusion: Immunosuppressive status and cellular immunity of patients after liver cancer surgery may be improved by a combination therapy of TPN, ω-3 PUFAs, Arg and glutamine.Keywords: Polyunsaturated fatty acid, Arginine, Glutamine, Parenteral nutrition, Hepatoma, Cellular immunity

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Zhixue, G., Ge, C., Han, B., Zengwang, Q., Yanjie, K., Ya, Z., Liqing, T., Feng, X., Xiaoyong, M., Liu, B. (2018). Effects of parenteral nutrition of ω-3 polyunsaturated fatty acid, arginine and glutamine on cellular immune status of patients following liver cancer surgery. https://doi.org/10.4314/tjpr.v17i3.17

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Auteur(s)

Guo Zhixue Changqing Ge Bing Han Qie Zengwang Kang Yanjie Zhu Ya Tian Liqing Xin Feng Ma Xiaoyong Bo Liu

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