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Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)

Article scientifique 2017 Anglais

Résumé

Introduction: There are few data available regarding natural history of local allergic rhinitis (LAR). We previously reported the results of the first 5-years of follow-up observing a similar rate of development of systemic allergic rhinitis (AR) in both LAR patients and healthy controls. Objective: To explore the natural history of a population with LAR and the development of AR and comorbidities over a 10 year period. Methods: A cohort of 194 patients with LAR of recent onset (<18 months) and 130 age-and sex-matched healthy controls were prospectively evaluated in a 10-year follow-up study (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016). All participants provided informed consent and ethic committee of the hospital approved the study. Clinical-demographic questionnaire, spirometry, SPT and specific IgE (sIgE) to aeroallergens were evaluated yearly. Nasal allergen provocation tests (NAPT) with D. pteronyssinus (DP), Alternaria, Olea europea, and grass pollen were performed at baseline, and after 5 and 10 years. Results: A total of 151 patients (78%) and 90 controls (69%) completed the study. At baseline, most patients had moderate-tosevere persistent-perennial rhinitis. Conjunctivitis (52%) and asthma (19%) were the main comorbidities, and DP the most frequent sensitizing aeroallergen (51.1%). During the 10 years of evaluation 21 new cases of asthma (12.5%, P = 0.007) and 17 new cases of conjunctivitis (10%, P = 0.067) were diagnosed. After 10 years of evolution a similar rate of development of AR was detected in patients and healthy controls (11.3 vs 10%, P = 0.761). In 5 patients, conversion to systemic atopy occurred in the last year of evaluation (3%). Conclusions: LAR is a well-differentiated clinical entity with a low rate of development of systemic atopy.

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Gracia, I., Rondón, C., Campo, P., Prieto, A., Mayorga, C., Galindo, L., Molina, A., Blanca, M., Torres, M., Morikawa, T., Fukuoka, A., Matsushita, K., Fujieda, S., Yoshimoto, T., Iwasaki, N., Smulders, T., Egmond, D., Drunen, K., Schee, M., Beule, A., Berings, M., Jult, A., Vermeulen, H., Ruyck, N., Derycke, L., Uçar, H., Ghekiere, P., Temmerman, R., Ellis, J., Bachert, C., Lambrecht, B., Dullaers, M., Gevaert, P., Arasi, S., Perna, S., Resch, Y., Lupinek, C., Chen, K., Vrtala, S., Valenta, R., Matricardi, P., Gonçalves, I., Jacinto, T., Amaral, R., Pereira, A., Araújo, L., Couto, M., Fonseca, J., Stjärne, P., Kaulsay, R., Pohl, W., Plaza, M., Prieto, A., Herknerová, M., Wang, T., Wu, C., Kilimajer, J., Pujols, L., Roca‐Ferrer, J., Callejas, F., Fuentes, M., Pérez, M., Alobid, I., Valero, A., Picado, C., Murray, R., Mullol, J., Steelant, B., Martens, K., Boeckxstaens, G., Seys, S., Hellings, P., Biggs, T., Hayes, S., Harries, P., Pender, S., Salib, R., Kim, J., Kim, J., Lee, H., Kalogjera, L., Vrkić, N., Topić, A., Tomljenović, D., Gregurić, T., Radovanović, P., Jund, R., Haimerl, P., Chaker, A., Schober, Y., Schindela, S., Nockher, A., Schmidt‐Weber, C., Bieren, J., Ickrath, P., Kleinsasser, N., Niklas, B., Ding, X., Hagen, R. (2017). Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017). https://doi.org/10.1186/s13601-017-0163-x

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Auteur(s)

Ibon Eguiluz Gracia Carmen Rondón Paloma Campo Ana Prieto Cristobalina Mayorga Luisa Galindo A. Criado Molina Miguel Blanca Marı́a José Torres Taiyo Morikawa Ayumi Fukuoka Kazufumi Matsushita Shigeharu Fujieda Tomohiro Yoshimoto Naruhito Iwasaki Tamar Smulders Daniëlle van Egmond Kees van Drunen Marc P. van der Schee Achim G. Beule Margot Berings Anton Jult Hanne Vermeulen Natalie De Ruyck Lara Derycke Hakan Uçar Philip Ghekiere Robin Temmerman John Ellis Claus Bachert Bart N. Lambrecht Mélissa Dullaers Philippe Gevaert Stefania Arasi Serena Perna Yvonne Resch Christian Lupinek Kuan‐Wei Chen Susanne Vrtala Rudolf Valenta Paolo Maria Matricardi Ivânia Gonçalves Tiago Jacinto Rita Amaral Ana Margarida Pereira Luís Araújo Mariana Couto João Fonseca Pär Stjärne Ranbir Kaulsay Wolfgang Pohl Maria Carmen Plaza Ana Maria Prieto Magdalena Herknerová Tengchin Wang Chiejun Wu Jonathan Kilimajer Laura Pujols Jordi Roca‐Ferrer Francisco de Borja Callejas Mireya Fuentes María Pérez Isam Alobid Antonio Valero César Picado Ruth Murray Joaquim Mullol Brecht Steelant Katleen Martens Guy E. Boeckxstaens Sven Seys Peter W. Hellings Timothy C. Biggs Stephen M. Hayes Philip G. Harries Sylvia L. F. Pender Rami J. Salib Jean Kim Hyun Sil Lee Livije Kalogjera Nada Vrkić Anita Topić Dejan Tomljenović Tomislav Gregurić P Radovanović R. Jund Pascal Haimerl Adam Chaker Yvonne Schober Sonja Schindela Andreas Nockher Carsten B. Schmidt‐Weber Julia Esser-Von Bieren Pascal Ickrath Norbert Kleinsasser Beyersdorf Niklas Xin Ding Rudolf Hagen

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