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COPD’s early origins in low-and-middle income countries: what are the implications of a false start?

Article scientifique 2019 Anglais

Résumé

The Global Initiative for chronic Obstructive Lung disease (GOLD) guideline of 2018 describes COPD as ‘the result of a complex interplay of long-term cumulative exposure to noxious gases and particles, combined with a variety of host factors including genetics, airway hyper-responsiveness and poor lung growth during childhood’. 1 Tobacco smoking is traditionally viewed as the main contributing factor to the development of COPD. However, COPD also occurs among non-smokers, especially in low-income and middle-income countries (LMICs). 2 , 3 Notably, more than 90% of COPD-related deaths occur in LMICs. 4 For these countries, other risk factors, such as ambient, occupational and household air pollution play a significant role in the development of COPD. 1 , 2 , 5 , 6 , 7 Does COPD in these settings have a different pathophysiological trajectory compared to COPD in high-income countries, and if so: what does this imply?

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Brakema, E., Gemert, F., Kleij, R., Salvi, S., Puhan, M., Chavannes, N., An, P., Anastasaki, M., Akmatalieva, M., Akylbekov, A., Barton, A., Bertsias, A., Binh, P., Boven, J., Burges, D., Cartwright, L., Chatzea, V., Cragg, L., Đăng, T., Dautov, I., Emilov, B., Ferarrio, I., Hedrick, B., Hong, L., Isaeva, E., Jones, R., Jong, C., Kampen, S., Katagira, W., Kirenga, B., Kjærgaard, J., Kocks, J., Lan, L., Linh, T., Lionis, C., Loan, K., Mademilov, M., McEwen, A., Musinguzi, P., Nantanda, R., Ndeezi, G., Papadakis, S., Pinnock, H., Pooler, J., Poot, C., Postma, M., Poulsen, A., Powell, P., Quỳnh, N., Reventlow, S., Sifaki‐Pistolla, D., Singh, S., Sooronbaev, T., Sousa, J., Stout, J., Stubbe-Østergaard, M., Tabyshova, A., Tsiligianni, I., Tumwine, J., Van, L., Vinh, N., Walusimbi, S., Warren, L., Williams, S. (2019). COPD’s early origins in low-and-middle income countries: what are the implications of a false start?. https://doi.org/10.1038/s41533-019-0117-y

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Auteur(s)

Evelyn A Brakema Frederik van Gemert Rianne van der Kleij Sundeep Salvi Milo A. Puhan Niels H. Chavannes Pham Lê An Marilena Anastasaki Meerim Akmatalieva Azamat Akylbekov Andy Barton Antonios Bertsias Pham Duong Uyen Binh Job F. M. van Boven Dennis Burges Lucy Cartwright Vasiliki‐Eirini Chatzea Liza Cragg Trần Ngọc Đăng Ilyas Dautov Berik Emilov Irene Ferarrio Ben Hedrick Le Huynh Thi Cam Hong Elvira Isaeva Rupert Jones Corina de Jong Sanne van Kampen Winceslaus Katagira Bruce Kirenga Jesper Kjærgaard Janwillem Kocks Le Thi Tuyet Lan Tran Thanh Duy Linh Christos Lionis Kim Xuan Loan Maamed Mademilov Andy McEwen Patrick Musinguzi Rebecca Nantanda Grace Ndeezi Sophia Papadakis Hilary Pinnock Jillian Pooler Charlotte C Poot Maarten J. Postma Anja Poulsen Pippa Powell Nguyĕn Nhật Quỳnh Susanne Reventlow Dimitra Sifaki‐Pistolla Sally Singh Talant Sooronbaev Jaime Correia de Sousa James W. Stout Marianne Stubbe-Østergaard Aizhamal Tabyshova Ioanna Tsiligianni James Tumwine Le Thanh Van Nguyen Nhu Vinh Simon Walusimbi Louise Warren Siân Williams

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