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Expression of Oct-4 in oncogenic miR-155-positive oral squamous carcinoma cells

Article scientifique 2016 Anglais

Résumé

Purpose: To identify effective molecular diagnostic methods for oral squamous cell carcinoma (OSCC) to facilitate treatment of the disease in its initial stages.Methods: To identify molecular markers, OSCC tissue samples were collected from cancer patients and healthy controls. CD44+ cells were sorted using quantitative real-time polymerase chain reaction (qRT-PCR). Immunohistochemistry and immunostaining experiments were performed to identify markers for OSCC.Results: The qRT-PCR data confirmed the presence of oncogenic miR-155 in the OSCC samples. The immunohistochemical and immunostaining results confirmed the expression of Oct-4, an important target for the early diagnosis of OSCC, in oncogenic miR-155-positive OSCCs.Conclusion: Detection of the expression of miR-155 and Oct-4, which are key molecular markers, may be useful in improving the early diagnosis of OSCC.Keywords: CD44, oral squamous cell carcinoma, oncogenic miR-155, Oct-4

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Jiang, J., Zhu, J., Han, H., Wang, Q. (2016). Expression of Oct-4 in oncogenic miR-155-positive oral squamous carcinoma cells. https://doi.org/10.4314/tjpr.v15i9.5

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Auteur(s)

Jun-Song Jiang Jia Zhu Hua Han Qing Wang

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