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Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.

Article scientifique 2020 Anglais

Résumé

Abstract Objective Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin. Results Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed to NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients. Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

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Tchiakpé, E., Kêkê, R., Vidal, N., Ahoussinou, C., Sekpe, O., Dagba, H., Gbaguidi, E., Tonoukouen, C., Afangnihoun, A., Bachabi, M., Gangbo, F., Diop‐Ndiaye, H., Kane, C. (2020). Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.. https://doi.org/10.21203/rs.3.rs-22911/v3

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Auteur(s)

Edmond Tchiakpé René Kpèmahouton Kêkê Nicole Vidal Clément Ahoussinou Olga Sekpe Hermione G Dagba Eric Gbaguidi Conrad Tonoukouen Aldric Afangnihoun Moussa Bachabi Flore Gangbo Halimatou Diop‐Ndiaye Coumba Touré Kane

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