Impact of Cotadutide Drug on Obese Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

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Abstract Background: The food and drug administration approved many drugs to treat diabetes mellitus, but those drugs do not have a noticeable effect on weight management. Recently, glucagon-like peptide 1 agonist known as Cotadutide was estimated to serve as a potent drug in treating type 2 diabetes by reducing blood glucose levels and body weight indices. This study aimed to explore the safety and efficacy of Cotadutide as a treatment for type 2 diabetes individuals.Methods: A comprehensive literature search was done on different databases, including PubMed, Scopus, Web of Science, and Cochrane Library to capture all relevant articles using an established search strategy. The inclusion criteria were randomized controlled trials that assessed the safety and efficacy of Cotadutide versus placebo or any anti-diabetes drugs in obese and overweight people with type 2 diabetes mellitus. Data analysis was accomplished using Revman 5.4 software.Results: We found 663 relevant articles. From which nine studies were included and subjected to qualitative analysis and eight for quantitative analysis. The pooled effect showed that Cotadutide was better than placebo in reducing body weight (Mean difference (MD) = 3.31, p > 0.00001), glycated hemoglobin (HbA1c ) (MD = -0.68, p > 0.00001), glucose area under the plasma concentration curve (AUC [0-4h]) (MD = 30.15, p > 0.00001), and fasting plasma glucose over time (mg/dl) (MD = 31.31, p > 0.00001).Conclusion: Cotadutide is safe and effective in reducing blood glucose levels and body weight in individuals with type 2 diabetes.Study protocol registration: The study protocol was registered on PROSPERO (CRD: CRD42021257670).

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