Accès ouvert

Review of: "Synthesis, ADME, Toxicity, and In Silico Molecular Docking Study of Novel β-Carboline Derivatives as Potential Inhibitor Anticancer Agents"

Article scientifique 2024 Anglais

Résumé

The author prepared and evaluated a series of new 5-(9-benzyl-1-methyl-9H-pyrido[3,4-b] indol-3-yl)-1,3,4oxadiazol-2-amine (4a-b).1H NMR, IR, and mass spectral data were used to evaluate the structures of the synthesized compounds.Besides the in silico molecular docking, which has been done on these newly synthesized compounds in the active pocket of Protein kinase inhibition by staurosporine PDB:1aq1 complex, it shows a good binding interaction in the active pocket of the PDB:1aq1 enzyme.The ADME and cytotoxicity properties suggest that this compound is best for further studies.

Citer ce document

Nemr, M. (2024). Review of: "Synthesis, ADME, Toxicity, and In Silico Molecular Docking Study of Novel β-Carboline Derivatives as Potential Inhibitor Anticancer Agents". https://doi.org/10.32388/5z7wpr

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Mohamed T. M. Nemr

Statistiques

Consultations : 1

Téléchargements : 0