Prevalence of Rifampicin resistance tuberculosis among presumptive tuberculosis patients in Egypt-2021: A National Health Facility-based Survey

Résumé

Abstract Background: The magnitude of MDR-TB cases was noticeable in Egypt. However, the last national survey was 11-years ago. The current survey was conducted to determine the prevalence of rifampicin resistance among sputum smear-positive tuberculosis patients in Egypt. Methods: A national health facility-based cross-sectional study was conducted in Egypt among presumptive tuberculosis (TB) cases during the period from August 2020 to September 2021. Rifampicin resistance (RR) was detected using the Gene X-pert MTB/RIF. The prevalence of RR was calculated using crude, cluster, and weighted methods. Factors associated with RR were analyzed by bivariate and multivariate techniques. Results: Among the total 849 presumptive TB patients enrolled in the study, 710 (83.6%) patients were subjected to Gene X-pert testing (MTB/RIF). The crude prevalence of RR was 3.32% (95% CI: 1.89-4.76%) among the new cases and 9.46% (95% CI: 2.63-16.29%) among the retreated cases with an overall estimate of 3.99%; (95% CI: 2.51- 5.47%). By cluster analysis the overall prevalence of RR was 5.01% (95% CI: 2.90–7.13). Factors associated with the prevalence of RR were co-morbidity with bronchial asthma, drug abuse and history of contact with a family member with TB. Conclusion: The prevalence of RR among either new or retreated cases TB patients was lower than the previous rates in 2010-2012. The strongest predictor associated with RR was comorbidity with bronchial asthma.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0