A modified HIV model with Beddington–DeAngelis incidence and cure rate

Résumé

This study presents a refined within-host human immunodeficiency virus (HIV) dynamics model that integrates several biologically relevant mechanisms often treated in isolation. The model incorporates a Beddington-DeAngelis functional response to describe the infection incidence, accounting for saturation effects in both target cells and free virus particles. It further includes a cure rate for infected cells, representing the efficacy of antiretroviral therapy or intrinsic immune clearance, and logistic growth for CD4[Formula: see text] T-cell populations. A novel contribution is the explicit inclusion of both cellular (cytotoxic T-lymphocytes, CTLs) and humoral (antibody) immune responses. We perform a complete dynamical analysis of the continuous-time system, deriving the basic reproduction number [Formula: see text] as a sharp threshold. We establish the existence and uniqueness of the disease-free and endemic equilibria and analyze their local stability. Furthermore, we prove the global asymptotic stability of the endemic equilibrium when [Formula: see text] using a Lyapunov function. To facilitate numerical investigation, we construct a dynamically consistent nonstandard finite difference (NSFD) discretization that preserves the positivity and stability properties of the continuous model. Numerical simulations validate the theoretical findings and illustrate the distinct roles of the saturation parameters [Formula: see text] and [Formula: see text], as well as the immune response, in modulating infection outcomes. The results highlight how the interplay between viral kinetics and immune effectors can determine disease progression or clearance, providing theoretical insights that could inform therapeutic strategies.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0