Editorial: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis and Pneumococcal Disease

Résumé

Platelets, best known as essential effector cells in coagulation and hemostasis, are increasingly recognized \nas major inflammatory cells that play a role in the innate and adaptive arms of the immune system. The \ninteraction of platelets with various cell types of the innate immune system, particularly neutrophils, as \nwell as with structural cells of the vascular endothelium, induces the release of platelet-derived mediators, \nthus exerting a protective effect in the physiologic response to diseases and control of invading \nmicroorganisms (1). However, it is also known that contrary to this protective anti-infective role of a \ntightly controlled activation of platelets, aberrant platelet activation can lead to systemic inflammation, \nwith organ dysfunction and thrombotic complications in both acute and chronic inflammatory disorders \nof infective origin. It is, therefore, pleasing that this Research Topic of Frontiers in Immunology contains \na series of up-to-date articles on the role of platelet activation in the pathophysiology of three important \nhost infections, namely the human immunodeficiency virus (HIV), Mycobacterium tuberculosis (TB) \nand Streptococcus pneumoniae (pneumococcus).

Citer ce document

Accès au document

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0